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Taurodeoxycholic acid
CAS No. 516-50-7
Taurodeoxycholic acid ( —— )
产品货号. M36631 CAS No. 516-50-7
Taurodeoxycholic acid 是一种胆汁酸，可稳定线粒体膜，减少自由基形成。Taurodeoxycholic acid 通过阻断钙介导的凋亡通路以及 Caspase-12 激活来抑制凋亡 (apoptosis)。Taurodeoxycholic acid 对 3-硝基丙酸诱导或稳定遗传的亨廷顿舞蹈病 (HD) 小鼠模型具有神经保护作用。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥724 | 有现货 |
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| 5MG | ￥953 | 有现货 |
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| 10MG | ￥1381 | 有现货 |
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| 25MG | ￥2244 | 有现货 |
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| 50MG | ￥3636 | 有现货 |
|
| 100MG | ￥5217 | 有现货 |
|
| 500MG | ￥10940 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Taurodeoxycholic acid
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Taurodeoxycholic acid 是一种胆汁酸，可稳定线粒体膜，减少自由基形成。Taurodeoxycholic acid 通过阻断钙介导的凋亡通路以及 Caspase-12 激活来抑制凋亡 (apoptosis)。Taurodeoxycholic acid 对 3-硝基丙酸诱导或稳定遗传的亨廷顿舞蹈病 (HD) 小鼠模型具有神经保护作用。
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产品描述Taurodeoxycholic acid, a bile acid, stabilizes the mitochondrial membrane, decreases free radical formation. Taurodeoxycholic acid inhibits apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid exhibits neuroprotective effect in 3-nitropropionic acid induced mouse model or genetic mouse model of Huntington's disease (HD).
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体外实验——
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体内实验Animal Model:Huntington's disease model in mouseDosage:50 mg/kg Administration:Intraperitoneal injection; once daliy for 34 d, injected 3-NP at 6 hr after Taurodeoxycholic acid treatment Result:Reduced striatal atrophy, decreased striatal apoptosis, as well as fewer and smaller size ubiquitinated neuronal intranuclear huntingtin inclusions.Significantly improved locomotor and sensorimotor deficits.
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同义词——
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通路Apoptosis
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靶点Apoptosis
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受体Apoptosis | Calcium Channel | Caspase
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研究领域——
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适应症——
化学信息
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CAS Number516-50-7
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分子量499.7
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分子式C26H45NO6S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 100 mg/mL (200.12 mM; 超声助溶 )
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SMILESC[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@H](O)CC4)[H])(C[C@@H]1O)[H])[H])(CC[C@@]2([C@@H](CCC(NCCS(=O)(=O)O)=O)C)[H])[H]
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
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NSC 745887
NSC 745887 是一种小分子，可通过捕获 DNA 拓扑异构酶裂解来有效抑制各种癌症的增殖。
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NM-3
NM-3 是一种异香豆素，具有抗关节炎和抗血管生成作用。NM-3 是一种具有口服活性的抗血管生成剂，毒性低。
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Cholesteryl Hemisucc...
Cholesteryl Hemisuccinate Tris Salt is an acidic cholesteryl ester with hepatoprotective and anticancer activity.Cholesteryl hemisuccinate is a membrane stabilizer in dipalmitoylphosphatidylcholine liposomes containing Chaikosaponin-d, which enhances the anticancer efficacy of cisplatin.Cholesteryl hemisuccinate possesses antitumor activity, inhibits tumor Cholesteryl hemisuccinate has antitumor activity, inhibits tumor growth, inhibits the hepatotoxicity of acetaminophen (AAP) and prevents AAP-induced apoptosis of hepatocytes.Cholesteryl hemisuccinate protects rodents against the toxic effects of acetaminophen, adriamycin, carbon tetrachloride, chloroform, and galactosamine.
